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Coumarin‐Caged Rosamine Probes Based on a Unique Intramolecular Carbon–Carbon Spirocyclization
Author(s) -
Lin Weiying,
Long Lingliang,
Tan Wen,
Chen Bingbing,
Yuan Lin
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201000015
Subject(s) - intramolecular force , fluorophore , carbon fibers , xanthene , fluorescence , computer science , chemistry , carbon chain , combinatorial chemistry , photochemistry , stereochemistry , organic chemistry , optics , physics , composite number , algorithm
Caged fluorophore : We report the first caging strategy for rosamine fluorophores based on a unique intramolecular carbon–carbon spirocyclization. The new class of carbon–carbon spirocyclic caged probes exhibit several significant advantages over the traditional nitrobenzyl‐caged xanthene probes and can be employed for spatially controlled fluorescence imaging of living cells (see graphic).