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Cover Picture: Crystal Structure of the T(6‐4)C Lesion in Complex with a (6‐4) DNA Photolyase and Repair of UV‐Induced (6‐4) and Dewar Photolesions (Chem. Eur. J. 40/2009)
Author(s) -
Glas Andreas F.,
Schneider Sabine,
Maul Melanie J.,
Hennecke Ulrich,
Carell Thomas
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200990154
Subject(s) - photolyase , dna repair , dna , dna damage , crystal structure , electron transfer , chemistry , crystal (programming language) , crystallography , stereochemistry , photochemistry , biochemistry , computer science , programming language
Fundamental repair… (6‐4) DNA photolyases repair mutagenic UV‐induced DNA lesions using a light‐triggered electron‐transfer‐based repair mechanism. The crystal structure of the (6‐4) photolyase from D. melanogaster in complex with DNA containing a site specific T(6‐4)C photoproduct, described by T. Carell et al. on page 10387 ff. , reveals the atomic details of one of the most fundamental enzymatic genome repair systems on Earth.