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Tertiary Skipped Diynes: A Pluripotent Building Block for the Modular and Diversity‐Oriented Synthesis of Nitrogen Heterocycles
Author(s) -
Tejedor David,
LópezTosco Sara,
GonzálezPlatas Javier,
GarcíaTellado Fernando
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200903577
Subject(s) - domino , block (permutation group theory) , modular design , chemistry , reactivity (psychology) , combinatorial chemistry , computer science , organic chemistry , mathematics , catalysis , combinatorics , medicine , alternative medicine , pathology , operating system
Dominos! The multivalent reactivity profile of tertiary skipped diynes has been conveniently exploited in the domino and diversity‐oriented synthesis of fully substituted pyrazoles and 1,4‐diazepane derivatives (see scheme). The developed manifold is chemically efficient and simple to operate. In addition, the resulting N‐containing heterocycles are obtained in a regio‐ and chemoselective manner.