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Copper‐Mediated Reductive Amination of Aryl Halides with Trimethylsilyl Azide
Author(s) -
Monguchi Yasunari,
Maejima Toshihide,
Mori Shigeki,
Maegawa Tomohiro,
Sajiki Hironao
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200903511
Subject(s) - azide , trimethylsilyl azide , aryl , amination , triethylamine , halide , amine gas treating , chemistry , copper , trimethylsilyl , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , alkyl
Look, no azide! Trimethylsilyl azide was reductively cross‐coupled with a variety of aryl halides in the presence of a copper species and amines, such as triethylamine or aminoethanol, to give the corresponding primary aryl amine in good yields without the formation of the expected aryl azide (see scheme).