A Three‐Component Reaction Based on a Remote‐Group‐Directed Dynamic Kinetic Aza‐Michael Addition: Stereoselective Synthesis of Imidazolidin‐4‐ones | Zendy

Xu Zhenghu | Zendy; Buechler Tyler | Zendy; Wheeler Kraig | Zendy; Wang Hong | Zendy

Premium

A Three‐Component Reaction Based on a Remote‐Group‐Directed Dynamic Kinetic Aza‐Michael Addition: Stereoselective Synthesis of Imidazolidin‐4‐ones

Author(s) -

Xu Zhenghu,

Buechler Tyler,

Wheeler Kraig,

Wang Hong

Publication year - 2010

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200903508

Subject(s) - michael reaction , stereoselectivity , aldehyde , amide , component (thermodynamics) , chemistry , computer science , stereochemistry , combinatorial chemistry , organic chemistry , physics , thermodynamics , catalysis

In control : An α‐amino amide reacted with an aldehyde and a Michael acceptor to form stable imidazolidin‐4‐ones with high stereoselectivity. A dynamic kinetic aza‐Michael addition was discovered and applied to the three‐component reaction to enforce high stereoselectivity. A remote group was incorporated to invert the reaction process and direct the reaction towards the desired product (see scheme).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research