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Enantioenrichment by Iterative Retro‐Aldol/Aldol Reaction Catalyzed by an Achiral or Racemic Base
Author(s) -
Flock Angelika M.,
Reucher Christine M. M.,
Bolm Carsten
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200903497
Subject(s) - aldol reaction , enantiomer , base (topology) , catalysis , chemistry , stereochemistry , organic chemistry , mathematics , mathematical analysis
Did nature use the same strategy? The combination of crystal growth and iterative retro‐aldol/aldol reactions catalyzed by a simple achiral (or racemic) base allows improvement of the enantiomer ratio of a product obtained from a stereochemically imperfect aldol reaction (see scheme).