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Small Molecule Macroarray Construction via Palladium‐Mediated CarbonCarbon Bond‐Forming Reactions: Highly Efficient Synthesis and Screening of Stilbene Arrays
Author(s) -
Frei Reto,
Blackwell Helen E.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200903445
Subject(s) - palladium , molecule , combinatorial chemistry , chemistry , small molecule , quorum sensing , cellulose , nanotechnology , catalysis , organic chemistry , materials science , biochemistry , gene , virulence
Arrays of stilbenes have been prepared in high purity by using Heck reactions on planar cellulose support, and demonstrate the compatibility of the small‐molecule macroarray platform (see figure) with metal‐mediated reactions for the first time. Biological screening of the stilbene library revealed several compounds with the ability to inhibit quorum sensing responses in bacteria, expanding the activity of this compound class.