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Naphthospironone A: An Unprecedented and Highly Functionalized Polycyclic Metabolite from an Alkaline Mine Waste Extremophile
Author(s) -
Ding ZhangGui,
Li MingGang,
Zhao JiangYuan,
Ren Jie,
Huang Rong,
Xie MingJin,
Cui XiaoLong,
Zhu HuaJie,
Wen MengLiang
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200903198
Subject(s) - metabolite , chemistry , stereochemistry , extremophile , organic chemistry , enzyme , biochemistry , thermophile
Bring in the new : Naphthospironone A ( 1 ), a novel polycyclic metabolite with an unprecedented spiro[bicyclo[3.2.1]octene‐pyran]dione ring system, was isolated from alkalophilic Nocardiopsis sp. (YIM DT266). Its complete structural assignment with the absolute stereochemistry was elucidated by spectroscopic data, X‐ray crystal diffraction, and calculation of optical rotation by using DFT methods. Naphthospironone A exhibited moderate cytotoxic and antibiotic bioactivities.