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Photochemistry of Visual Pigment in a G q Protein‐Coupled Receptor (GPCR)—Insights from Structural and Spectral Tuning Studies on Squid Rhodopsin
Author(s) -
Sekharan Sivakumar,
Altun Ahmet,
Morokuma Keiji
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200903194
Subject(s) - rhodopsin , squid , counterion , chromophore , chemistry , g protein coupled receptor , retinal , photochemistry , receptor , ion , biology , biochemistry , organic chemistry , ecology
Chemistry of vision in an invertebrate : A comprehensive QM/MM evaluation of the structure and spectral tuning mechanism of squid rhodopsin is reported for the first time. A negatively charged Glu180 residue is found to be the principal counterion and the strong electrostatic interaction between the 11‐ cis ‐retinal chromophore and counterion is responsible for the origin of spectral tuning from gas phase (604 nm) to the protein environment (490 nm).