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Selective Ruthenium‐Catalyzed N‐Alkylation of Indoles by Using Alcohols
Author(s) -
Bähn Sebastian,
Imm Sebastian,
Mevius Kathleen,
Neubert Lorenz,
Tillack Annegret,
Williams Jonathan M. J.,
Beller Matthias
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200903144
Subject(s) - alkylation , catalysis , ruthenium , chemistry , homogeneous , organic chemistry , solid acid , physics , thermodynamics
Alcohols for alkylation! The first homogeneous‐catalyzed N‐alkylations of indoles with aliphatic alcohols proceed under transfer hydrogenation conditions. By the use of the Shvo catalyst and p ‐toluenesulfonic acid (PTSA) this atom‐efficient reaction occurs highly selectively with water formed as the only byproduct (see scheme).