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Asymmetric Substitutions of 2‐Lithiated N ‐Boc‐piperidine and N ‐Boc‐azepine by Dynamic Resolution
Author(s) -
Coldham Iain,
Raimbault Sophie,
Whittaker David T. E.,
Chovatia Praful T.,
Leonori Daniele,
Patel Jignesh J.,
Sheikh Nadeem S.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200903059
Subject(s) - piperidine , kinetic resolution , azepine , electrophile , chemistry , enantiomer , ligand (biochemistry) , trimethylsilyl , enantiomeric excess , stereochemistry , enantioselective synthesis , chiral ligand , combinatorial chemistry , catalysis , organic chemistry , biochemistry , receptor
Abstract Proton abstraction of N ‐ tert ‐butoxycarbonyl‐piperidine ( N ‐Boc‐piperidine) with s BuLi and TMEDA provides a racemic organolithium that can be resolved using a chiral ligand. The enantiomeric organolithiums can interconvert so that a dynamic resolution occurs. Two mechanisms for promoting enantioselectivity in the products are possible. Slow addition of an electrophile such as trimethylsilyl chloride allows dynamic resolution under kinetic control (DKR). This process occurs with high enantioselectivity and is successful by catalysis with substoichiometric chiral ligand (catalytic dynamic kinetic resolution). Alternatively, the two enantiomers of this organolithium can be resolved under thermodynamic control with good enantioselectivity (dynamic thermodynamic resolution, DTR). The best ligands found are based on chiral diamino‐alkoxides. Using DTR, a variety of electrophiles can be used to provide an asymmetric synthesis of enantiomerically enriched 2‐substituted piperidines, including (after Boc deprotection) the alkaloid (+)‐β‐conhydrine. The chemistry was extended, albeit with lower yields, to the corresponding 2‐substituted seven‐membered azepine ring derivatives.