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Construction of a Tetracyclic Butterfly‐Like Scaffold: Palladium‐Catalyzed Heck/Arylation Cascade
Author(s) -
Kim Ko Hoon,
Lee Hyun Seung,
Kim Sung Hwan,
Kim Se Hee,
Kim Jae Nyoung
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200903029
Subject(s) - palladium , domino , cascade , catalysis , cascade reaction , chemistry , combinatorial chemistry , heck reaction , yield (engineering) , butterfly , scaffold , organic chemistry , materials science , biology , computer science , metallurgy , ecology , chromatography , database
Controlled carbopalladation : Only slight changes in the starting material (see scheme) resulted in rather different compounds in palladium‐catalyzed domino reactions. A novel tetracyclic butterfly‐like scaffold was constructed in a one‐pot reaction via the Pd‐catalyzed 5‐ exo‐trig carbopalladation and arylation cascade in high yield.