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[PdCl 2 (MeCN) 2 ]‐Catalyzed Highly Regio‐ and Stereoselective Allylation of Electron‐Rich Arenes with 2,3‐Allenoates
Author(s) -
Fang Zhao,
Fu Chunling,
Ma Shengming
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200903012
Subject(s) - anisole , stereoselectivity , chemistry , phenol , dimethylacetamide , palladium , catalysis , organic chemistry , medicinal chemistry , combinatorial chemistry , solvent
Selective allylation : Several electron‐donating arenes such as 1,3,5‐trimethoxybenzene, anisole, and phenol underwent palladium‐catalyzed selective allylation in TFA/dimethylacetamide (DMA) under mild conditions with 2,3‐allenoates (see scheme). The reaction afforded substituted 4,4‐diarylbut‐2( E )‐enoates in moderate yields with high regio‐ and stereoselectivity.