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Structure‐Based Design of Highly Crowded Ribostamycin/Kanamycin Hybrids as a New Family of Antibiotics
Author(s) -
Revuelta Julia,
Vacas Tatiana,
Corzana Francisco,
Gonzalez Carlos,
Bastida Agatha,
Asensio Juan Luis
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200903003
Subject(s) - kanamycin , complementation , sugar , simple (philosophy) , computer science , biology , genetics , antibiotics , biochemistry , gene , philosophy , epistemology , phenotype
Sugar sugar! The synthesis and evaluation of ribostamycin/kanamycin hybrids incorporating a highly crowded trisubstituted aminocyclitol unit that should provide maximum complementation with the RNA receptor are reported (see picture). Analysis shows that the existing conflicts between the different sugar rings can be significantly alleviated by a simple chemical modification, leading to an improvement in activity.