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Trihydroxytrioxatriangulene—An Extended Fluorescein and a Ratiometric pH Sensor
Author(s) -
Westerlund Fredrik,
Hildebrandt Christoffer B.,
Sørensen Thomas J.,
Laursen Bo W.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200902965
Subject(s) - fluorescein , fluorescence , protonation , chemistry , computer science , combinatorial chemistry , optics , organic chemistry , physics , ion
Fluorescein ver. 2.0 : A new, highly fluorescent, pH‐sensitive trihydroxytrioxatriangulenium dye (H‐TOTA) has been synthesised and characterised. The dye is closely related to fluorescein and may be considered to be a two‐dimensional extended version. This new dye can exist in four different protonation states (see graphic) depending on the pH, and its use as a sensitive fluorescent ratiometric pH probe in a physiological buffer is demonstrated.