Reaction Mechanism for the LiCl‐Mediated Directed Zinc Insertion: A Computational and Experimental Study | Zendy

Liu ChingYuan | Zendy; Wang Xuan | Zendy; Furuyama Taniyuki | Zendy; Yasuike Shuji | Zendy; Muranaka Atsuya | Zendy; Morokuma Keiji | Zendy; Uchiyama Masanobu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Reaction Mechanism for the LiCl‐Mediated Directed Zinc Insertion: A Computational and Experimental Study

Author(s) -

Liu ChingYuan,

Wang Xuan,

Furuyama Taniyuki,

Yasuike Shuji,

Muranaka Atsuya,

Morokuma Keiji,

Uchiyama Masanobu

Publication year - 2010

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200902957

Subject(s) - zinc , lithium (medication) , regioselectivity , insertion reaction , chemistry , mechanism (biology) , reaction mechanism , lithium chloride , computational chemistry , combinatorial chemistry , organic chemistry , catalysis , physics , psychology , quantum mechanics , psychiatry

Tired of wondering about the role of LiCl in the DoI reaction of zinc? Kinetic/thermodynamic competitive experiments and DFT calculations were performed to clarify the regioselectivity and reaction mechanism/pathways of lithium chloride‐promoted directed zinc insertion into bromobenzenes. The results strongly suggest that the LiCl‐containing “push–pull form” transition state ( TS b ) is formed at an early stage, thus accelerating the reaction rate of zinc insertion. (DoI=directed ortho insertion.)

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research