The First General, Efficient and Highly Enantioselective Reduction of Quinoxalines and Quinoxalinones | Zendy

Rueping Magnus | Zendy; Tato Francisco | Zendy; Schoepke Fenja. R. | Zendy

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The First General, Efficient and Highly Enantioselective Reduction of Quinoxalines and Quinoxalinones

Author(s) -

Rueping Magnus,

Tato Francisco,

Schoepke Fenja. R.

Publication year - 2010

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200902907

Subject(s) - enantioselective synthesis , computer science , simple (philosophy) , combinatorial chemistry , reduction (mathematics) , scheme (mathematics) , chemistry , organic chemistry , catalysis , mathematics , philosophy , epistemology , geometry , mathematical analysis

Simple yet efficient : A series of diverse substituted tetrahydroquinoxalines and dihydroquinoxalinones have been synthesized for the first time in a highly enantioselective fashion (see scheme). Using this metal‐free hydrogenation it is possible to isolate these products, which are of high pharmaceutical interest, in good yields and with excellent enantioselectivities in a minimal number of reaction steps.

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