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The First General, Efficient and Highly Enantioselective Reduction of Quinoxalines and Quinoxalinones
Author(s) -
Rueping Magnus,
Tato Francisco,
Schoepke Fenja. R.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200902907
Subject(s) - enantioselective synthesis , computer science , simple (philosophy) , combinatorial chemistry , reduction (mathematics) , scheme (mathematics) , chemistry , organic chemistry , catalysis , mathematics , philosophy , epistemology , geometry , mathematical analysis
Simple yet efficient : A series of diverse substituted tetrahydroquinoxalines and dihydroquinoxalinones have been synthesized for the first time in a highly enantioselective fashion (see scheme). Using this metal‐free hydrogenation it is possible to isolate these products, which are of high pharmaceutical interest, in good yields and with excellent enantioselectivities in a minimal number of reaction steps.