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Anatomy of Long‐Lasting Love Affairs with Lithium Carbenoids: Past and Present Status and Future Prospects
Author(s) -
Capriati Vito,
Florio Saverio
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200902870
Subject(s) - lithium (medication) , maturity (psychological) , solvation , chemistry , organic synthesis , reactivity (psychology) , field (mathematics) , psychology , engineering ethics , nanotechnology , epistemology , computational chemistry , organic chemistry , philosophy , medicine , engineering , materials science , mathematics , catalysis , psychiatry , developmental psychology , alternative medicine , pathology , ion , pure mathematics
After a long adolescence, the chemistry of lithium carbenoids has currently been entering its maturity bringing a dowry of a more in‐depth and less empirical knowledge of the structure and configurational stability of such double‐faced intermediates; this, thanks in particular to the synergistic and harmonic cooperation between calculations and the most modern NMR techniques now at our disposal. Such knowledge has stimulated the development of fruitful stereoselective applications in the field of organic synthesis, providing in addition a rationale to observed selectivities. Such aspects together with the role played by aggregation and solvation on the structure–reactivity relationship are highlighted throughout this Minireview with selected examples extracted from recent literature.