Dynamic Kinetic Asymmetric Transformation (DYKAT) by Combined Amine‐ and Transition‐Metal‐Catalyzed Enantioselective Cycloisomerization | Zendy

Zhao GuiLing | Zendy; Ullah Farman | Zendy; Deiana Luca | Zendy; Lin Shuangzheng | Zendy; Zhang Qiong | Zendy; Sun Junliang | Zendy; Ibrahem Ismail | Zendy; Dziedzic Pawel | Zendy; Córdova Armando | Zendy

Premium

Dynamic Kinetic Asymmetric Transformation (DYKAT) by Combined Amine‐ and Transition‐Metal‐Catalyzed Enantioselective Cycloisomerization

Author(s) -

Zhao GuiLing,

Ullah Farman,

Deiana Luca,

Lin Shuangzheng,

Zhang Qiong,

Sun Junliang,

Ibrahem Ismail,

Dziedzic Pawel,

Córdova Armando

Publication year - 2010

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200902818

Subject(s) - cycloisomerization , enantioselective synthesis , catalysis , amine gas treating , kinetic energy , transition metal , chemistry , transformation (genetics) , combinatorial chemistry , stereochemistry , organic chemistry , physics , biochemistry , quantum mechanics , gene

The first examples of one‐pot highly chemo‐ and enantioselective dynamic kinetic asymmetric transformations (DYKATs) involving α,β‐unsaturated aldehydes and propargylated carbon acids are presented. These DYKATs, which proceed by a combination of catalytic iminium activation, enamine activation, and Pd 0 ‐catalyzed enyne cycloisomerization, give access to functionalized cyclopentenes with up to 99 % ee and can be used for the generation of all‐carbon quaternary stereocenters.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research