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N , N′ ‐Methylenediimidazolium Salts: From Self‐Assembly to an Efficient DNAse Protection System
Author(s) -
Pardin Christophe,
Leclercq Loïc,
Schmitzer Andreea R.
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200902794
Subject(s) - cationic polymerization , cleavage (geology) , dna , vesicle , chemistry , deoxyribonuclease i , stereochemistry , combinatorial chemistry , biochemistry , biology , polymer chemistry , membrane , base sequence , paleontology , fracture (geology)
We have developed N , N′ ‐dialkylmethylenediimidazolium salts ([C n C n DIM][X] 2 ) that self‐organize into multilayered cationic vesicles and can interact with DNA. These preorganized systems form complexes with linear DNA and protect it from DNase I cleavage.