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OFF–ON Fluorescent Detection of Thymidine Nucleotides by a Zinc(II)–Cyclen Complex Bearing Two Diagonal Pyrenes
Author(s) -
Zeng Zhanghua,
Spiccia Leone
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200902734
Subject(s) - cyclen , nucleotide , fluorescence , thymidine , chemistry , pyrene , zinc , stereochemistry , dna , biochemistry , organic chemistry , physics , optics , gene
A fluorescent chemosensor consisting of a Zn II –cyclen complex bearing two diagonal pyrenes (see picture) has been developed that has a high affinity for thymidine nucleotides, and exhibits a much greater enhancement in pyrene excimer emission for thymidine triphosphate, ‐diphosphate and ‐monophosphate than for the other DNA bases and a variety of nucleotides.