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Diastereoselective Benzylic Arylation of Tetralins
Author(s) -
Davoust Marion,
Kitching Jacki A.,
Fleming Matthew J.,
Lautens Mark
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200902694
Subject(s) - enantiopure drug , tetralin , chemistry , scope (computer science) , aryl , substrate (aquarium) , intermolecular force , organic chemistry , combinatorial chemistry , catalysis , computer science , molecule , enantioselective synthesis , alkyl , oceanography , geology , programming language
Friedel–Crafts protocols for the intermolecular, trans ‐selective benzylic arylation of tetralin systems are described (see scheme). The protocols have broad substrate scope and the use of enantiopure substrates allows the preparation of trans ‐aryl‐substituted tetralins in high ee.