Asymmetric Organocatalytic N‐Alkylation of Indole‐2‐carbaldehydes with α,β‐Unsaturated Aldehydes: One‐Pot Synthesis of Chiral Pyrrolo[1,2‐ a ]indole‐2‐carbaldehydes | Zendy

Hong Liang | Zendy; Sun Wangsheng | Zendy; Liu Chunxia | Zendy; Wang Lei | Zendy; Wang Rui | Zendy

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Asymmetric Organocatalytic N‐Alkylation of Indole‐2‐carbaldehydes with α,β‐Unsaturated Aldehydes: One‐Pot Synthesis of Chiral Pyrrolo[1,2‐ a ]indole‐2‐carbaldehydes

Author(s) -

Hong Liang,

Sun Wangsheng,

Liu Chunxia,

Wang Lei,

Wang Rui

Publication year - 2010

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200902638

Subject(s) - indole test , enantioselective synthesis , chemistry , alkylation , cascade , catalysis , combinatorial chemistry , organic chemistry , chromatography

Like water from a duck's back : A highly enantioselective organocatalytic cascade aza‐Michael/aldol reaction of indole‐2‐carbaldehydes with α,β‐unsaturated aldehydes has been developed, providing an easy access to pyrrolo[1,2‐ a ]indole‐2‐carbaldehydes with moderate to excellent enantioselectivities in one single reaction (see scheme).

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