Premium
Asymmetric Organocatalytic N‐Alkylation of Indole‐2‐carbaldehydes with α,β‐Unsaturated Aldehydes: One‐Pot Synthesis of Chiral Pyrrolo[1,2‐ a ]indole‐2‐carbaldehydes
Author(s) -
Hong Liang,
Sun Wangsheng,
Liu Chunxia,
Wang Lei,
Wang Rui
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200902638
Subject(s) - indole test , enantioselective synthesis , chemistry , alkylation , cascade , catalysis , combinatorial chemistry , organic chemistry , chromatography
Like water from a duck's back : A highly enantioselective organocatalytic cascade aza‐Michael/aldol reaction of indole‐2‐carbaldehydes with α,β‐unsaturated aldehydes has been developed, providing an easy access to pyrrolo[1,2‐ a ]indole‐2‐carbaldehydes with moderate to excellent enantioselectivities in one single reaction (see scheme).