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Asymmetric S N 1 α‐Alkylation of Cyclic Ketones Catalyzed by Functionalized Chiral Ionic Liquid (FCIL) Organocatalysts
Author(s) -
Zhang Long,
Cui Lingyun,
Li Xin,
Li Jiuyuan,
Luo Sanzhong,
Cheng JinPei
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200902509
Subject(s) - desymmetrization , ionic liquid , alkylation , catalysis , stereoselectivity , chemistry , enantioselective synthesis , ionic bonding , intermolecular force , combinatorial chemistry , organic chemistry , molecule , ion
Ionic liquid works better : The first intermolecular asymmetric α‐alkylation of cyclic ketones was realized by using functionalized chiral ionic liquids as catalysts. The reaction proceeded with good to excellent yields and high ee. Highly stereoselective desymmetrization of 4‐substituted cyclohexanones with >99:1 d.r. and up to 87 % ee were achieved by using this protocol.