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Use of β,γ‐Unsaturated α‐Ketocarbonyls for a Totally Regioselective Oxidative Multicomponent Synthesis of Polyfunctionalized Pyridines
Author(s) -
Allais Christophe,
Constantieux Thierry,
Rodriguez Jean
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200902491
Subject(s) - regioselectivity , oxidative phosphorylation , chemistry , combinatorial chemistry , organic chemistry , biochemistry , catalysis
Versatile partners : α‐Ketocarbonyls have been shown for the first time to be versatile partners in a Michael addition promoted oxidative domino three‐component reaction under heterogeneous conditions. This multicomponent reaction sequence led to the development of a general synthesis of highly functionalized pyridines (see scheme), allowing selective and simultaneous incorporation of a substituent at the 4‐position and a synthetically useful functionality at the strategic 2‐position.