Use of β,γ‐Unsaturated α‐Ketocarbonyls for a Totally Regioselective Oxidative Multicomponent Synthesis of Polyfunctionalized Pyridines

Versatile partners : α‐Ketocarbonyls have been shown for the first time to be versatile partners in a Michael addition promoted oxidative domino three‐component reaction under heterogeneous conditions. This multicomponent reaction sequence led to the development of a general synthesis of highly functionalized pyridines (see scheme), allowing selective and simultaneous incorporation of a substituent at the 4‐position and a synthetically useful functionality at the strategic 2‐position.