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Copper‐Catalyzed Enantioselective Hydrosilylation of Ketones by Using Monodentate Binaphthophosphepine Ligands
Author(s) -
Junge Kathrin,
Wendt Bianca,
Addis Daniele,
Zhou Shaolin,
Das Shoubhik,
Beller Matthias
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200902442
Subject(s) - hydrosilylation , denticity , enantioselective synthesis , chemistry , alkyl , aryl , copper , catalysis , base (topology) , organic chemistry , polymer chemistry , medicinal chemistry , crystal structure , mathematical analysis , mathematics
No base required : The first copper‐catalyzed asymmetric hydrosilylation of carbonyl compounds by using monodentate binaphthophosphepine ligands is presented. After optimization of the reaction parameters, high yields and enantioselectivities (up to 96 % ee ) for a broad range of aryl alkyl, cyclic, heterocyclic, and aliphatic ketones are achieved without a base.