Copper‐Catalyzed Enantioselective Hydrosilylation of Ketones by Using Monodentate Binaphthophosphepine Ligands | Zendy

Junge Kathrin | Zendy; Wendt Bianca | Zendy; Addis Daniele | Zendy; Zhou Shaolin | Zendy; Das Shoubhik | Zendy; Beller Matthias | Zendy

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Copper‐Catalyzed Enantioselective Hydrosilylation of Ketones by Using Monodentate Binaphthophosphepine Ligands

Author(s) -

Junge Kathrin,

Wendt Bianca,

Addis Daniele,

Zhou Shaolin,

Das Shoubhik,

Beller Matthias

Publication year - 2010

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200902442

Subject(s) - hydrosilylation , denticity , enantioselective synthesis , chemistry , alkyl , aryl , copper , catalysis , base (topology) , organic chemistry , polymer chemistry , medicinal chemistry , crystal structure , mathematical analysis , mathematics

No base required : The first copper‐catalyzed asymmetric hydrosilylation of carbonyl compounds by using monodentate binaphthophosphepine ligands is presented. After optimization of the reaction parameters, high yields and enantioselectivities (up to 96 % ee ) for a broad range of aryl alkyl, cyclic, heterocyclic, and aliphatic ketones are achieved without a base.

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