Premium
Energy Triplets for Writing Epigenetic Marks: Insights from QM/MM Free‐Energy Simulations of Protein Lysine Methyltransferases
Author(s) -
Xu Qin,
Chu Yuzhuo,
Guo HaoBo,
Smith Jeremy C.,
Guo Hong
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200902297
Subject(s) - methyltransferase , epigenetics , methylation , lysine , computer science , energy (signal processing) , readability , genetics , computational biology , biology , gene , physics , programming language , amino acid , quantum mechanics
Modeling methylation : The free‐energy profiles for methyl transfers in DIM‐5 (see picture) and its mutants are well correlated with experimentally observed product specificities. The simulation results, therefore, suggest that the relative efficiencies of the methyl transfers may determine how the epigenetic marks of lysine methylation are written.