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Toward Efficient Palladium‐Catalyzed Allylic CH Alkylation
Author(s) -
Jensen Thomas,
Fristrup Peter
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200901935
Subject(s) - tsuji–trost reaction , palladium , alkylation , catalysis , allylic rearrangement , chemistry , combinatorial chemistry , organic chemistry
Recent breakthroughs have proved that direct palladium(II)‐catalyzed allylic CH alkylation can be achieved. This new procedure shows that the inherent requirement for a leaving group in the Tsuji–Trost palladium‐catalyzed allylic alkylation can be lifted. These initial reports hold great promise for the development of allylic CH alkylation into a widely applicable methodology, thus providing a means to enhance synthetic efficiency in these reactions.