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Iminium‐Ion Activation as an Efficient Strategy for Divergent Synthesis of Optically Active Propargylic, Homopropargylic, and Allenic Compounds
Author(s) -
Jiang Hao,
Holub Nicole,
Paixão Márcio W.,
Tiberi Caterina,
Falcicchio Aurelia,
Jørgensen Karl Anker
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200901921
Subject(s) - iminium , optically active , conjugate , computer science , combinatorial chemistry , chemistry , ion , organic chemistry , mathematics , mathematical analysis
Assemble and build : The strategy depicted above merges different organocatalyzed conjugate addition reactions with the Seyferth–Gilmann homologation by which diverse optically active propargylic, homopropargylic and allenic products can be assembled in high yields and enantioselectivities.