Premium
Methanol‐Assisted Catalysis by Chiral Tin Methoxides: An Alternative Asymmetric Aldol Process
Author(s) -
Yanagisawa Akira,
Satou Tomoya,
Izumiseki Atsuto,
Tanaka Youichi,
Miyagi Masahiko,
Arai Takayoshi,
Yoshida Kazuhiro
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200901822
Subject(s) - aldol reaction , tin , sodium methoxide , catalysis , enantioselective synthesis , methanol , chemistry , organic chemistry , process development , process engineering , engineering
Opening a tin of catalysts : A catalytic enantioselective aldol reaction of alkenyl trichloroacetates with aldehydes was achieved using a ( S )‐BINOL‐derived chiral organotin(IV) dibromide possessing a 4‐ tert ‐butylphenyl group at the 3‐ and 3′‐position as a chiral pre‐catalyst in the presence of sodium methoxide and methanol (see scheme).