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Au Nanowire–Au Nanoparticles Conjugated System which Provides Micrometer Size Molecular Sensors
Author(s) -
Kang Taejoon,
Yoon Ilsun,
Kim Jangbae,
Ihee Hyotcherl,
Kim Bongsoo
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200901708
Subject(s) - micrometer , nanotechnology , materials science , raman scattering , nanoparticle , conjugated system , nanowire , substrate (aquarium) , biotinylation , raman spectroscopy , multiplex , nanosensor , chemistry , optics , polymer , biochemistry , oceanography , physics , geology , composite material , bioinformatics , biology
We report a new type of molecular sensor using a Au nanowire (NW)–Au nanoparticles (NPs) conjugated system. The Au NW–NPs structure is fabricated by the self‐assembly of biotinylated Au NPs on a biotinylated Au NW through avidin; this creates hot spots between NW and NPs that strongly enhance the Raman signal. The number of the Au NPs attached to the NW is reproducibly proportional to the concentration of the avidin, and is also proportional to the measured surface‐enhanced Raman scattering (SERS) signals. Since this well‐defined NW–NPs conjugated sensor is only a few micrometer long, we expect that development of multiplex nanobiosensor of a few tens micrometer size would become feasible by combining individually modified multiple Au NWs together on one substrate.