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Generating Complexity from Simplicity: Pd‐Catalyzed or Cu‐Promoted Domino Alkyne Homocoupling/Double [2+2] Allenyne Cycloaddition
Author(s) -
Alcaide Benito,
Almendros Pedro,
Aragoncillo Cristina
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200901574
Subject(s) - alkyne , domino , bimetallic strip , cycloaddition , catalysis , chemistry , combinatorial chemistry , ring (chemistry) , medicinal chemistry , organic chemistry
An efficient Pd–Cu bimetallic catalyzed or Cu‐promoted preparation of attached‐ring bis(heterocyclic) fused cyclobutenes in a totally controlled fashion by using alkyne homocoupling, as well as a double [2+2] cyclization of the resulting bis(allenyne) in a domino sequence has been accomplished (see scheme).