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A Gold‐Catalyzed Cascade Reaction Involving an Unusual Intramolecular Redox Process
Author(s) -
Barluenga José,
Fernández Amadeo,
Rodríguez Félix,
Fañanás Francisco J.
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200901557
Subject(s) - intramolecular force , chemistry , catalysis , ketone , intermolecular force , redox , cascade reaction , cascade , intramolecular reaction , photochemistry , reaction mechanism , derivative (finance) , combinatorial chemistry , medicinal chemistry , organic chemistry , molecule , financial economics , economics , chromatography
Gold catalysis : Secondary 5‐hexyn‐1‐ol derivatives react with indoles and other heteroaromatic compounds under gold‐catalyzed conditions to give the corresponding ketone derivative (see scheme) through a cascade reaction involving an initial intramolecular hydroalkoxylation reaction of the triple bond followed by an intermolecular hydroarylation reaction and an unusual intramolecular Oppenauer‐type oxidation process.