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Rhodium‐Catalyzed Asymmetric [5+2] Cycloaddition of Alkyne–Vinylcyclopropanes
Author(s) -
Shintani Ryo,
Nakatsu Hiroki,
Takatsu Keishi,
Hayashi Tamio
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200901463
Subject(s) - rhodium , alkyne , cycloaddition , catalysis , chemistry , medicinal chemistry , organic chemistry
Easy to scale : A rhodium‐catalyzed asymmetric intramolecular [5+2] cycloaddition of alkyne–vinylcyclopropanes has been developed. High enantioselectivities of up to >99.5 % ee have been achieved by the use of a chiral phosphoramidite ligand. The reaction can be easily scaled up and the stereochemical model of the present catalysis has also been proposed.