Designing Caspase‐3 Sensors for Imaging of Apoptosis in Living Cells | Zendy

Chen Ning | Zendy; Huang Yun | Zendy; Yang Lily | Zendy; Liu Rihe | Zendy; Yang Jenny J. | Zendy

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Designing Caspase‐3 Sensors for Imaging of Apoptosis in Living Cells

Author(s) -

Chen Ning,

Huang Yun,

Yang Lily,

Liu Rihe,

Yang Jenny J.

Publication year - 2009

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200901439

Subject(s) - green fluorescent protein , apoptosis , caspase , intracellular , microbiology and biotechnology , caspase 3 , fluorescence , chemistry , sensitivity (control systems) , biophysics , biochemistry , biology , programmed cell death , gene , physics , engineering , electronic engineering , optics

Powerful ratiometric sensor : The caspase–cascade system plays a vital role in intracellular apoptotic signals associated with various human diseases. A single EGFP‐based (EGFP, enhanced green fluorescent protein) caspase‐3 sensor was successfully developed to track the activation and inhibition of caspase‐3 in living cells in real time with a high sensitivity and enzymatic selectivity in a ratiometric measurement mode.

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