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Single‐Domain Antibody‐Conjugated Nanoaggregate‐Embedded Beads for Targeted Detection of Pathogenic Bacteria
Author(s) -
Huang PingJi,
Tay LiLin,
Tanha Jamshid,
Ryan Shan,
Chau LaiKwan
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200901397
Subject(s) - single domain antibody , staphylococcus aureus , pathogenic bacteria , bacteria , conjugated system , antibody , phage display , chemistry , materials science , microbiology and biotechnology , nanotechnology , biology , polymer , immunology , genetics , organic chemistry
Cells aglow : Nanoaggregate‐embedded beads (NAEBs) linked to a pathogen‐specific single‐domain antibody (sdAb) are used as an ultra‐bright surface‐enhanced Raman scattering (SERS) tag for detection of Staphylococcus aureus bacteria by SERS microscopy. The image shows a single S. aureus cell labeled with NAEBs and its corresponding NAEB–SERS spectrum.