Improving the Trapping of Superoxide Radical with a β‐Cyclodextrin– 5‐Diethoxyphosphoryl‐5‐methyl‐1‐pyrroline‐ N ‐oxide (DEPMPO) Conjugate | Zendy

Hardy Micaël | Zendy; Bardelang David | Zendy; Karoui Hakim | Zendy; Rockenbauer Antal | Zendy; Finet JeanPierre | Zendy; Jicsinszky Laszlo | Zendy; Rosas Roselyne | Zendy; Ouari Olivier | Zendy; Tordo Paul | Zendy

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Improving the Trapping of Superoxide Radical with a β‐Cyclodextrin– 5‐Diethoxyphosphoryl‐5‐methyl‐1‐pyrroline‐ N ‐oxide (DEPMPO) Conjugate

Author(s) -

Hardy Micaël,

Bardelang David,

Karoui Hakim,

Rockenbauer Antal,

Finet JeanPierre,

Jicsinszky Laszlo,

Rosas Roselyne,

Ouari Olivier,

Tordo Paul

Publication year - 2009

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200901342

Subject(s) - superoxide , conjugate , adduct , chemistry , spin trapping , cyclodextrin , pyrroline , superoxide radical , photochemistry , stereochemistry , organic chemistry , mathematical analysis , mathematics , enzyme

Trapped spin trap : CD‐DEPMPO, a cyclodextrin–DEPMPO conjugate spin trap, exhibits improved performances in superoxide detection. Using blood as a biological model system, the superoxide CD‐DEPMPO adduct was still unambiguously detected after 70 min, whereas using DEPMPO the signal of the superoxide adduct was not detected. (DEPMPO=5‐diethoxyphosphoryl‐5‐methyl‐1‐pyrroline‐ N ‐oxide.)

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