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Improving the Trapping of Superoxide Radical with a β‐Cyclodextrin– 5‐Diethoxyphosphoryl‐5‐methyl‐1‐pyrroline‐ N ‐oxide (DEPMPO) Conjugate
Author(s) -
Hardy Micaël,
Bardelang David,
Karoui Hakim,
Rockenbauer Antal,
Finet JeanPierre,
Jicsinszky Laszlo,
Rosas Roselyne,
Ouari Olivier,
Tordo Paul
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200901342
Subject(s) - superoxide , conjugate , adduct , chemistry , spin trapping , cyclodextrin , pyrroline , superoxide radical , photochemistry , stereochemistry , organic chemistry , mathematical analysis , mathematics , enzyme
Trapped spin trap : CD‐DEPMPO, a cyclodextrin–DEPMPO conjugate spin trap, exhibits improved performances in superoxide detection. Using blood as a biological model system, the superoxide CD‐DEPMPO adduct was still unambiguously detected after 70 min, whereas using DEPMPO the signal of the superoxide adduct was not detected. (DEPMPO=5‐diethoxyphosphoryl‐5‐methyl‐1‐pyrroline‐ N ‐oxide.)