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Asymmetric, Regioselective Direct Aldol Coupling of Enones and Aldehydes with Chiral Rhodium(bis‐oxazolinylphenyl) Catalysts
Author(s) -
Mizuno Masato,
Inoue Hiroko,
Naito Tatsuo,
Zhou Li,
Nishiyama Hisao
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200901329
Subject(s) - regioselectivity , rhodium , aldol reaction , chemistry , enantioselective synthesis , selectivity , catalysis , coupling (piping) , organic chemistry , combinatorial chemistry , materials science , metallurgy
Boxing clever : A chiral rhodium(bis‐oxazolinyl) complex 1 exhibited catalytic activity for the asymmetric, regioselective direct coupling of cyclic enones and aldehydes (see scheme). The products were obtained with high anti selectivity up to 97 % and with up to 94 % ee.