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A Simple and Efficient Catalytic System for N‐Arylation of Imidazoles in Water
Author(s) -
Wang Yi,
Wu Zhiqing,
Wang Lixia,
Li Zhengkai,
Zhou Xiangge
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200901232
Subject(s) - simple (philosophy) , catalysis , halide , aryl , computer science , protocol (science) , combinatorial chemistry , functional group , scheme (mathematics) , chemistry , mathematics , organic chemistry , medicine , philosophy , alkyl , alternative medicine , epistemology , pathology , polymer , mathematical analysis
N‐Arylation in water! A simple and highly efficient protocol for the N‐arylation of imidazoles with aryl halides in water catalyzed by a sulfonato–Cu(salen) complex (see scheme) has been developed. This novel strategy requires only mild reaction conditions and has excellent functional‐group tolerance. The water‐soluble catalyst can be recovered easily and reused at least three times without obvious detriment to the catalytic abilities.