Highly Diastereoselective Gold‐ or Copper‐Catalyzed Formal [4+3] Cycloaddition of 1‐(1‐Alkynyl) Cyclopropyl Ketones and Nitrones | Zendy

Bai Yu | Zendy; Fang Jie | Zendy; Ren Jun | Zendy; Wang Zhongwen | Zendy

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Highly Diastereoselective Gold‐ or Copper‐Catalyzed Formal [4+3] Cycloaddition of 1‐(1‐Alkynyl) Cyclopropyl Ketones and Nitrones

Author(s) -

Bai Yu,

Fang Jie,

Ren Jun,

Wang Zhongwen

Publication year - 2009

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.200901133

Subject(s) - cycloisomerization , cycloaddition , domino , furan , chemistry , combinatorial chemistry , bicyclic molecule , catalysis , stereochemistry , organic chemistry

Domino day : A highly diastereoselective Cu‐ or Au‐catalyzed tandem cycloisomerization/formal [4+3] cycloaddition of 1‐(1‐alkynyl) cyclopropyl ketones and nitrones has been developed (see scheme) along with an efficient one‐pot, three‐component version of this reaction. This methodology provides a route to a new type of 5/7‐bicyclic heterocycle: a furan‐fused oxazepine.

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