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Atropisomerism of α,β‐Unsaturated Amidines: Stereoselective Synthesis by Catalytic Cascade Reaction and Optical Resolution
Author(s) -
Shindoh Naoya,
Takemoto Yoshiji,
Takasu Kiyosei
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200901103
Subject(s) - stereoselectivity , atropisomer , cascade , chemistry , catalysis , resolution (logic) , combinatorial chemistry , stereochemistry , organic chemistry , computer science , artificial intelligence , chromatography
Torquoselective : Enantiomers of axially chiral α,β‐unsaturated amidines were prepared by catalytic cascade reactions consisting of [2+2] cycloaddition and thermal cycloreversion. The cascade reaction proceeds in a stereoselective (torquoselective) manner, confirmed by the intermediate depicted.