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Highly Enantioselective Sulfenylation of β‐Ketoesters: H‐Bond Acceptor Catalysis
Author(s) -
Fang Ling,
Lin Aijun,
Hu Hongwen,
Zhu Chengjian
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200901099
Subject(s) - enantioselective synthesis , steric effects , catalysis , acceptor , chemistry , hydrogen bond , combinatorial chemistry , organic chemistry , stereochemistry , molecule , physics , condensed matter physics
A new mode of activation : The asymmetric diarylprolinol‐catalyzed α‐sulfenylation of β‐ketoesters provides the products in good‐to‐excellent enantioselectivities and yields. Studies suggest that the sterically bulky secondary amines activate β‐ketoesters through hydrogen bonding. Lg=leaving group.