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Hyperpolarized Amino Acids for In Vivo Assays of Transaminase Activity
Author(s) -
Jensen Pernille R.,
Karlsson Magnus,
Meier Sebastian,
Duus Jens Ø.,
Lerche Mathilde H.
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200901042
Subject(s) - in vivo , transaminase , amino acid , chemistry , yield (engineering) , biochemistry , computer science , biology , microbiology and biotechnology , materials science , enzyme , metallurgy
Novel markers : NMR spectroscopy has a unique potential to monitor chemical reactions in vivo (see figure). Unlike other imaging techniques, non‐invasive NMR experiments yield information on the chemical nature of educts and products through their chemical shifts. The hyperpolarization of amino acids for in vivo assays of transaminase activity is shown.