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Formal Highly Enantioselective Organocatalytic Addition of Fluoromethyl Anion to α,β‐Unsaturated Aldehydes
Author(s) -
Alba AndreaNekane,
Companyó Xavier,
Moyano Albert,
Rios Ramon
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900991
Subject(s) - enantioselective synthesis , scheme (mathematics) , chemistry , computer science , organic chemistry , combinatorial chemistry , mathematics , catalysis , mathematical analysis
S ymmetric fluoromethylation made easy : A highly enantioselective fluoromethyl addition to α,β‐unsaturated aldehydes is described (see scheme). The synthesis of chiral fluorinated blocks, including δ‐fluoro‐β‐aminoalcohol derivatives is disclosed.