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First Enantioselective Synthesis of ( R )‐Convolutamydine B and E with N ‐(Heteroarenesulfonyl)prolinamides
Author(s) -
Hara Noriyuki,
Nakamura Shuichi,
Shibata Norio,
Toru Takeshi
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900944
Subject(s) - enantioselective synthesis , aldol reaction , bifunctional , stereochemistry , computer science , chemistry , organic chemistry , catalysis
Crossed‐aldol reaction : The synthesis of ( R )‐convolutamydine E has been achieved by the crossed‐aldol reaction of acetaldehyde with 4,6‐dibromoisatin ( 1 : X = Y = Br) by using a bifunctional organocatalyst. This strategy allows the enantioselective synthesis of ( R )‐convolutamydine E derivatives and convolutamydine B.