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A New and Flexible Synthesis of 4‐Hydroxypyridines: Rapid Access to Caerulomycins A, E and Functionalized Terpyridines
Author(s) -
Dash Jyotirmayee,
Reissig HansUlrich
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900939
Subject(s) - scheme (mathematics) , simple (philosophy) , computer science , combinatorial chemistry , chemistry , database , mathematics , philosophy , mathematical analysis , epistemology
Simple, but yet unknown : 1,3‐Diketones, ammonia, and carboxylic acids are the precursors for the efficient synthesis of 4‐hydroxypyridines and the corresponding nonaflate derivatives. This provides simple and practical access to a variety of highly substituted pyridine derivatives, including antibiotic natural products such as caerulomycins A, E and functionalized terpyridines (see scheme).