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Metallotherapeutics: Novel Strategies in Drug Design
Author(s) -
Hocharoen Lalintip,
Cowan James A.
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900821
Subject(s) - biomolecule , rna , chemistry , ribose , drug , biochemistry , hydrolysis , nucleic acid , enzyme , side chain , combinatorial chemistry , amino acid , stereochemistry , biophysics , computational biology , biology , pharmacology , organic chemistry , gene , polymer
A new paradigm for drug activity is presented, which includes both recognition and subsequent irreversible inactivation of therapeutic targets. Application to both RNA and protein biomolecules has been demonstrated. In contrast to RNA targets that are subject to strand scission chemistry mediated by ribose H‐atom abstraction, proteins appear to be inactivated either through oxidative damage to amino acid side chains around the enzyme active site, or by backbone hydrolysis.