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A Multicomponent Reaction Towards N ‐(Cyanomethyl)amides
Author(s) -
Elders Niels,
Ruijter Eelco,
de Kanter Frans J. J.,
Janssen Elwin,
Lutz Martin,
Spek Anthony L.,
Orru Romano V. A.
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900785
Subject(s) - reagent , catalysis , chemistry , scope (computer science) , combinatorial chemistry , organic chemistry , reaction conditions , functional diversity , medicinal chemistry , computer science , programming language , ecology , biology
Diversity‐oriented synthesis : The multicomponent reaction of α‐isocyano amides, aldehydes or ketones, and amines affords N ‐(cyanomethyl)amides, presenting the fourth class of products from this combination of reagents (see scheme). The scope of the reaction is very broad and various functional groups are tolerated. The outcome of the reaction can also be directed to the formation of 2 H ‐2‐imidazolines by Ag I catalysis.