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Cell‐Permeable [ 99m Tc(CO 3 )]‐Labeled Fluorogenic Caspase 3 Substrate for Dual‐Modality Detection of Apoptosis
Author(s) -
Xiong Chiyi,
Lu Wei,
Zhang Rui,
Tian Mei,
Tong William,
Gelovani Juri,
Li Chun
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900766
Subject(s) - apoptosis , substrate (aquarium) , in vivo , chemistry , modality (human–computer interaction) , cell , caspase , caspase 3 , biophysics , microbiology and biotechnology , programmed cell death , biochemistry , biology , computer science , artificial intelligence , ecology
To image apoptosis in vivo, a small, membrane‐permeable probe comprising a caspase 3 substrate, a fluorogenic dye, and a radionuclide was synthesized (see scheme). This dual‐modality probe was specifically cleaved by caspase 3 upon exposure to apoptotic cells, allowing the imaging of caspase 3 activities (see figure) and apoptosis by using both optical and nuclear imaging techniques.