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Diversity‐Oriented Synthesis of Morpholine‐Containing Molecular Scaffolds
Author(s) -
Lalli Claudia,
Trabocchi Andrea,
Sladojevich Filippo,
Menchi Gloria,
Guarna Antonio
Publication year - 2009
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200900744
Subject(s) - morpholine , diversity (politics) , scheme (mathematics) , pairing , chemistry , computer science , information retrieval , combinatorial chemistry , mathematics , organic chemistry , physics , sociology , superconductivity , quantum mechanics , anthropology , mathematical analysis
Couple and cyclize : A coupling–cyclization strategy employing building blocks from the chiral pool was applied for the generation of morpholine‐containing scaffolds (see scheme). The modulation of both the reaction conditions and the stereochemistry of the building blocks allowed the first degree of skeletal diversity, followed by functional group pairing of strategic appendages of selected molecular scaffolds to achieve more complex molecular frameworks.